Grace Brennan


Contact Details

Postdoctoral researcher
MS1-033-07, MSSI
University of Limerick
Limerick
Ireland
E: grace.brennan@ul.ie
researcher

Biography

https://scholar.google.com/citations?hl=en&user=MqvC84QAAAAJ

Currently working on:
1.   Nonlinear optical characterisation of hybrid plasmonic nanodiscs and waveguides
2.   Nanocrystal-based LEDs optical and electrical characterisation (low-temperature, time-resolved and DC biased photoluminescence, electron microscopy and photolithography)
3.   ASINA H2020 project - optical characterisation

Under the supervision of Dr Ning Liu and Prof Tofail Syed. 


PhD in Physics, University of Limerick                         2016-2020
BSc in Applied Physics, University of Limerick             2012-2016

Research Interests

Plasmonics, microscopy, spectroscopy, magnetics, and nanomaterials.
https://scholar.google.com/citations?hl=en&user=MqvC84QAAAAJ&view_op=list_works&gmla=AJsN-F5Pm9NA9LK...


Through optical characterisation of multistage magnetite-gold (Fe3O4-Au) core-shell nanostructures, we found a substantial spectral drift between the optical scattering and extinction. Furthermore, we observed that this spectral drift enhances the photothermal behaviour of such nanostructures, facilitating spectrally selective photothermal therapy and diagnostic imaging.
https://doi.org/10.1039/D0NR01463J


Combined laser dark field microscopy and epi-detected coherent anti-Stokes Raman (CARS) microscopy to image the uptake of magnetic-plasmonic nanoparticles in human pancreatic cancer cells.
https://doi.org/10.3390/nano11030685



For this study, we quantified the efficacy of magnetic iron oxide cores with various gold shell thicknesses in a number of popular magnetic-based nanotheranostic applications; these included magnetic sorting and targeting (quantifying magnetic manipulability and magnetophoresis), MRI contrasting (quantifying benchtop nuclear magnetic resonance (NMR)-based T1 and T2 relaxivity), and magnetic hyperthermia therapy (quantifying alternating magnetic-field heating). We observed a general decrease in magnetic response and efficacy with an increase of the gold shell thickness.
https://doi.org/10.3390/nano10122424

Peer Reviewed Journals

Year Publication
2021 'Dark Field and Coherent Anti-Stokes Raman (DF-CARS) Imaging of Cell Uptake of Core-Shell, Magnetic-Plasmonic Nanoparticles'
Grace Brennan;Sally Ryan;Tewfik Soulimane;Syed A. M. Tofail;Christophe Silien; (2021) 'Dark Field and Coherent Anti-Stokes Raman (DF-CARS) Imaging of Cell Uptake of Core-Shell, Magnetic-Plasmonic Nanoparticles'. Journal Of Nanomaterials, [DOI] [Details]
2021 'Photo-responsive functional gold nanocapsules for inactivation of community-acquired, highly virulent, multidrug-resistant MRSA'
Nanasaheb D. Thorat;Ewa Dworniczek;Grace Brennan;Grzegorz Chodaczek;Rabah Mouras;Victoria Gascón Pérez;Christophe Silien;Syed A. M. Tofail;Joanna Bauer; (2021) 'Photo-responsive functional gold nanocapsules for inactivation of community-acquired, highly virulent, multidrug-resistant MRSA'. Journal Of Materials Chemistry B, [DOI] [Details]
2020 'The Effects of a Varied Gold Shell Thickness on Iron Oxide Nanoparticle Cores in Magnetic Manipulation, T1 and T2 MRI Contrasting, and Magnetic Hyperthermia'
Grace Brennan;Silvia Bergamino;Martina Pescio;Syed A. M. Tofail;Christophe Silien; (2020) 'The Effects of a Varied Gold Shell Thickness on Iron Oxide Nanoparticle Cores in Magnetic Manipulation, T1 and T2 MRI Contrasting, and Magnetic Hyperthermia'. Journal Of Nanomaterials, [DOI] [Details]
2020 'Spectral drifts in surface textured Fe3O4-Au, core-shell nanoparticles enhance spectra-selective photothermal heating and scatter imaging'
Brennan G.;Thorat N.D.;Pescio M.;Bergamino S.;Bauer J.;Liu N.;Tofail S.A.M.;Silien C. (2020) 'Spectral drifts in surface textured Fe3O4-Au, core-shell nanoparticles enhance spectra-selective photothermal heating and scatter imaging'. Nanoscale, 12 (23):12632-12638 [DOI] [Details]
2020 'Spectral drifts in surface textured Fe3O4-Au, core–shell nanoparticles enhance spectra-selective photothermal heating and scatter imaging'
Grace Brennan;Nanasaheb D. Thorat;Martina Pescio;Silvia Bergamino;Joanna Bauer;Ning Liu;Syed A. M. Tofail;Christophe Silien; (2020) 'Spectral drifts in surface textured Fe3O4-Au, core–shell nanoparticles enhance spectra-selective photothermal heating and scatter imaging'. Nanoscale, [DOI] [Details]
2020 'Erratum: Progress in remotely triggered hybrid nanostructures for next-generation brain cancer theranostics (ACS Biomaterials Science & Engineering (2019) 5:6 (2669−2687) DOI: 10.1021/acsbiomaterials.8b01173)'
Thorat, N.D.;Townley, H.;Brennan, G.;Parchur, A.K.;Silien, C.;Bauer, J.;Tofail, S.A.M.; (2020) 'Erratum: Progress in remotely triggered hybrid nanostructures for next-generation brain cancer theranostics (ACS Biomaterials Science & Engineering (2019) 5:6 (2669−2687) DOI: 10.1021/acsbiomaterials.8b01173)'. Acs Biomaterials Science & Engineering, [DOI] [Details]
2020 'Characterisation and Manipulation of Polarisation Response in Plasmonic and Magneto-Plasmonic Nanostructures and Metamaterials'
(2020) 'Characterisation and Manipulation of Polarisation Response in Plasmonic and Magneto-Plasmonic Nanostructures and Metamaterials'. Symmetry, [DOI] [Details]
2019 'Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations'
Nanasaheb D. Thorat;Syed A. M. Tofail;Brigitte von Rechenberg;Helen Townley;Grace Brennan;Christophe Silien;Hemraj M. Yadav;Thomas Steffen;Joanna Bauer; (2019) 'Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations'. Applied Physics Reviews, [DOI] [Details]
2019 'Synthesis and Characterization of CuZnSe2 Nanocrystals in Wurtzite, Zinc Blende, and Core-Shell Polytypes'
Ren H.;Wang M.;Li Z.;Laffir F.;Brennan G.;Sun Y.;Stokes K.;Geaney H.;O'Reilly E.;Gao P.;Liu N.;McCarthy C.;Ryan K. (2019) 'Synthesis and Characterization of CuZnSe2 Nanocrystals in Wurtzite, Zinc Blende, and Core-Shell Polytypes'. Chemistry Of Materials, [DOI] [Details]
2019 'Progress in Remotely Triggered Hybrid Nanostructures for Next-Generation Brain Cancer Theranostics'
Thorat N.;Townely H.;Brennan G.;Parchur A.;Silien C.;Bauer J.;Tofail S. (2019) 'Progress in Remotely Triggered Hybrid Nanostructures for Next-Generation Brain Cancer Theranostics'. Acs Biomaterials Science & Engineering, [DOI] [Details]
2019 'Synthesis and Characterization of CuZnSe2 Nanocrystals in Wurtzite, Zinc Blende, and Core–Shell Polytypes'
(2019) 'Synthesis and Characterization of CuZnSe2 Nanocrystals in Wurtzite, Zinc Blende, and Core–Shell Polytypes'. Chemistry Of Materials, [DOI] [Details]

Professional Associations

  Association Function From / To
Institute of Physics Member /

Employment

  Employer Position From / To
University of Limerick Postdoctoral researcher /

Education

  Year Institution Qualification Subject
2016 University of Limerick BSc Applied Physics
2020 University of Limerick PhD Physics