Martina O'Keeffe


Contact Details

Senior Technical Officer

 
researcher

Biography

Dr. Martina O'Keeffe completed her PhD on the role of pericytes in tumour angiogenesis in the University of Ulster in 2003, following which she took up post-doctoral and research fellow positions in University College Dublin and at the University of Limerick. Martina has been a Senior Technical Officer in the Department of Biological Sciences at UL since 2017 where she supports both undergraduate labs and postgraduate research. 

Book Chapters

  Year Publication
2016 'Milk Protein Hydrolysates and Bioactive Peptides'
AB Nongonierma, MB O’keeffe, RJ FitzGerald (2016) 'Milk Protein Hydrolysates and Bioactive Peptides' In: Advanced Dairy Chemistry Volume 1B: Proteins: Applied Aspects. New York: Springer. [DOI] [Details]

Peer Reviewed Journals

  Year Publication
2020 'Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity'
Harnedy-Rothwell P.;McLaughlin C.;O'Keeffe M.;Le Gouic A.;Allsopp P.;McSorley E.;Sharkey S.;Whooley J.;McGovern B.;O'Harte F.;FitzGerald R. (2020) 'Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity'. Food Research International, 131 [DOI] [ULIR Link] [Details]
2019 'Peptide identification from a Porphyra dioica protein hydrolysate with antioxidant, angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory activities'
Maria Cermeno;Julianne Stack;Paul R. Tobin;Martina B. O'Keeffe;Pádraigín A. Harnedy;Dagmar B. Stengel;Richard J. FitzGerald; (2019) 'Peptide identification from a Porphyra dioica protein hydrolysate with antioxidant, angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory activities'. Food & Function, [DOI] [Details]
2019 'Identification of bioactive peptides from brewers¿ spent grain and contribution of Leu/Ile to bioactive potency'
Cermeño M.;Connolly A.;O'Keeffe M.;Flynn C.;Alashi A.;Aluko R.;FitzGerald R. (2019) 'Identification of bioactive peptides from brewers¿ spent grain and contribution of Leu/Ile to bioactive potency'. Journal Of Functional Foods, 60 [DOI] [Details]
2019 'Immunomodulatory activity of 5 kDa permeate fractions of casein hydrolysates generated using a range of enzymes in Jurkat T cells and RAW264.7 macrophages'
O'Sullivan, SM;O'Callaghan, YC;O'Keeffe, MB;FitzGerald, RJ;O'Brien, NM (2019) 'Immunomodulatory activity of 5 kDa permeate fractions of casein hydrolysates generated using a range of enzymes in Jurkat T cells and RAW264.7 macrophages'. International Dairy Journal, 91 :9-17 [DOI] [Details]
2018 'Whey protein hydrolysate induced modulation of endothelial cell gene expression'
O'Keeffe, MB,FitzGerald, RJ (2018) 'Whey protein hydrolysate induced modulation of endothelial cell gene expression'. Journal Of Functional Foods, 40 :102-109 [DOI] [Details]
2018 'Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides'
Harnedy, PA;Parthsarathy, V;McLaughlin, CM;O'Keeffe, MB;Allsopp, PJ;McSorley, EM;O'Harte, FPM;FitzGerald, RJ (2018) 'Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides'. Food Research International, 106 :598-606 [DOI] [ULIR Link] [Details]
2017 'Purification and identification of antioxidant peptides from gelatin hydrolysates of unicorn leatherjacket skin'
Karnjanapratum, S.;O'Callaghan, Y.C.;Benjakul, S.;O'Keeffe, M.B.;FitzGerald, R.J.;O'Brien, N.M.; (2017) 'Purification and identification of antioxidant peptides from gelatin hydrolysates of unicorn leatherjacket skin'. Italian Journal of Food Science, [Details]
2002 'Tumour cell radiosensitization using constitutive (CMV) and radiation inducible (WAF1) promoters to drive the iNOS gene: A novel suicide gene therapy'
Worthington, J.;Robson, T.;O'Keeffe, M.;Hirst, D.G.; (2002) 'Tumour cell radiosensitization using constitutive (CMV) and radiation inducible (WAF1) promoters to drive the iNOS gene: A novel suicide gene therapy'. Gene Therapy, [DOI] [Details]
2018 'Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties'
Harnedy, PA,Parthsarathy, V,McLaughlin, CM,O'Keeffe, MB,Allsopp, PJ,McSorley, EM,O'Harte, FPM,FitzGerald, RJ (2018) 'Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties'. Journal Of Functional Foods, 40 :137-145 [DOI] [ULIR Link] [Details]
2017 'Identification of angiotensin converting enzyme inhibitory and antioxidant peptides in a whey protein concentrate hydrolysate produced at semi-pilot scale'
O'Keeffe, MB,Conesa, C,FitzGerald, RJ (2017) 'Identification of angiotensin converting enzyme inhibitory and antioxidant peptides in a whey protein concentrate hydrolysate produced at semi-pilot scale'. International Journal Of Food Science And Technology, 52 :1751-1759 [DOI] [Details]
2017 'Fractionation and identification of antioxidant peptides from an enzymatically hydrolysed Palmaria palmata protein isolate'
Harnedy, PA,O'Keeffe, MB,FitzGerald, RJ (2017) 'Fractionation and identification of antioxidant peptides from an enzymatically hydrolysed Palmaria palmata protein isolate'. Food Research International, 100 :416-422 [DOI] [ULIR Link] [Details]
2017 'Peptide identification in a salmon gelatin hydrolysate with antihypertensive, dipeptidyl peptidase IV inhibitory and antioxidant activities'
Neves, AC,Harnedy, PA,O'Keeffe, MB,Alashi, MA,Aluko, RE,FitzGerald, RJ (2017) 'Peptide identification in a salmon gelatin hydrolysate with antihypertensive, dipeptidyl peptidase IV inhibitory and antioxidant activities'. Food Research International, 100 :112-120 [DOI] [Details]
2017 'Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity'
O'Keeffe, MB,Norris, R,Alashi, MA,Aluko, RE,FitzGerald, RJ (2017) 'Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity'. Journal Of Functional Foods, 34 :77-88 [DOI] [Details]
2017 'Purification and identification of antioxidant peptides from gelatin hydrolysate of seabass skin'
Sae-Leaw, T,Karnjanapratum, S,O'Callaghan, YC,O'Keeffe, MB,FitzGerald, RJ,O'Brien, NM,Benjakul, S (2017) 'Purification and identification of antioxidant peptides from gelatin hydrolysate of seabass skin'. Journal Of Food Biochemistry, 41 [DOI] [Details]
2017 'Bioactive peptides from Atlantic salmon (Salmo salar) with angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory, and antioxidant activities'
Neves, AC,Harnedy, PA,O'Keeffe, MB,FitzGerald, RJ (2017) 'Bioactive peptides from Atlantic salmon (Salmo salar) with angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory, and antioxidant activities'. Food chemistry, 218 :396-405 [DOI] [Details]
2017 'Isolation of peptides from a novel brewers spent grain protein isolate with potential to modulate glycaemic response'
Connolly, A,O'Keeffe, MB,Nongonierma, AB,Piggott, CO,FitzGerald, RJ (2017) 'Isolation of peptides from a novel brewers spent grain protein isolate with potential to modulate glycaemic response'. International Journal Of Food Science And Technology, 52 :146-153 [DOI] [Details]
2016 'Purification and identification of antioxidant peptides from gelatin hydrolysate of seabass skin'
Thanasak Sae‐Leaw, Supatra Karnjanapratum, Yvonne C O'Callaghan, Martina B O'Keeffe, Richard J FitzGerald, Nora M O'Brien, Soottawat Benjakul (2016) 'Purification and identification of antioxidant peptides from gelatin hydrolysate of seabass skin'. Journal Of Food Biochemistry, [DOI] [Details]
2015 'Identification of short peptide sequences in complex milk protein hydrolysates'
O'Keeffe, MB,FitzGerald, RJ (2015) 'Identification of short peptide sequences in complex milk protein hydrolysates'. Food chemistry, 184 :140-146 [DOI] [Details]
2015 'Generation and identification of angiotensin converting enzyme (ACE) inhibitory peptides from a brewers' spent grain protein isolate'
Connolly, A,O'Keeffe, MB,Piggott, CO,Nongonierma, AB,FitzGerald, RJ (2015) 'Generation and identification of angiotensin converting enzyme (ACE) inhibitory peptides from a brewers' spent grain protein isolate'. Food Chemistry, 176 :64-71 [DOI] [Details]
2015 'Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes'
Kleekayai, T, Harnedy, PA, O'Keeffe, MB, Poyarkov, AA, CunhaNeves, A, Suntornsuk, W, FitzGerald, RJ (2015) 'Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes'. Food Chemistry, 176 :441-447 [DOI] [Details]
2015 'Peptide identification and angiotensin converting enzyme (ACE) inhibitory activity in prolyl endoproteinase digests of bovine alpha(s)-casein'
Norris, R,O'Keeffe, MB,Poyarkov, A,FitzGerald, RJ (2015) 'Peptide identification and angiotensin converting enzyme (ACE) inhibitory activity in prolyl endoproteinase digests of bovine alpha(s)-casein'. Food chemistry, 188 :210-217 [DOI] [Details]
2015 'Fractionation and identification of Alaska pollock skin collagen-derived mineral chelating peptides'
Guo, LD,Harnedy, PA,O'Keeffe, MB,Zhang, L,Li, BF,Hou, H,FitzGerald, RJ (2015) 'Fractionation and identification of Alaska pollock skin collagen-derived mineral chelating peptides'. Food chemistry, 173 :536-542 [DOI] [Details]
2015 'Purification and identification of dipeptidyl peptidase (DPP) IV inhibitory peptides from the macroalga Palmaria palmata'
Harnedy PA, O'Keeffe MB, FitzGerald RJ (2015) 'Purification and identification of dipeptidyl peptidase (DPP) IV inhibitory peptides from the macroalga Palmaria palmata'. Food Chemistry, 172 :400-406 [DOI] [Details]
2014 'Characterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine beta-casein and determination of ACE inhibitory activity'
Norris, R,Poyarkov, A,O'Keeffe, MB,FitzGerald, RJ (2014) 'Characterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine beta-casein and determination of ACE inhibitory activity'. Food Chemistry, 156 :29-36 [DOI] [Details]
2014 'Antioxidant activity of bovine casein hydrolysates produced by Ficus carica L.-derived proteinase'
Di Pierro, G,O'Keeffe, MB,Poyarkov, A,Lomolino, G,FitzGerald, RJ (2014) 'Antioxidant activity of bovine casein hydrolysates produced by Ficus carica L.-derived proteinase'. Food Chemistry, 156 :305-311 [DOI] [Details]
2014 'Antioxidant effects of enzymatic hydrolysates of whey protein concentrate on cultured human endothelial cells'
O'Keeffe, MB,FitzGerald, RJ (2014) 'Antioxidant effects of enzymatic hydrolysates of whey protein concentrate on cultured human endothelial cells'. International Dairy Journal, 36 :128-135 [DOI] [Details]
2013 'Substrate specificity of glutamyl endopeptidase (GE): hydrolysis studies with a bovine α-casein preparation'
Kalyankar P, Zhu Y, O'Keeffe M, O'Cuinn G, FitzGerald RJ. (2013) 'Substrate specificity of glutamyl endopeptidase (GE): hydrolysis studies with a bovine α-casein preparation'. Food Chemistry, 136 (2):501-512 [DOI] [Details]
2008 'Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPase'
O'Keeffe MB, Reid HM, Kinsella BT (2008) 'Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPase'. Biochimica et biophysica acta, 1783 (10):1914-1928 [DOI] [Details]
2008 'Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase'
Wikstrom K, Reid HM, Hill M, English KA, O'Keeffe MB, Kimbembe CC, Kinsella BT (2008) 'Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase'. Cellular signalling, 20 (12):2332-2346 [DOI] [Details]
2008 'Investigation of pericytes, hypoxia, and vascularity in bladder tumors: Association with clinical outcomes'
O'Keeffe, MB; Devlin, AH; Burns, AJ; Gardiner, TA; Logan, ID; Hirst, DG; McKeown, SR (2008) 'Investigation of pericytes, hypoxia, and vascularity in bladder tumors: Association with clinical outcomes'. ONCOLOGY RESEARCH, 17 (3):93-101 [Details]
2007 'Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling'
Kelley-Hickie LP, O'Keeffe MB, Reid HM, Kinsella BT (2007) 'Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling'. Biochimica et biophysica acta, 1773 (6):970-989 [DOI] [Details]
2005 '15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells'
Coyle AT, O'Keeffe MB, Kinsella BT (2005) '15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells'. The FEBS journal, 272 (18):4754-4773 [DOI] [Details]

Magazine Article

  Year Publication
2015 Potential immunomodulatory effects of casein-derived bioactive peptides in human T cells.
O'Sullivan, SM,O'Callaghan, YC,O'Keeffe, MB,FitzGerald, RJ,O'Brien, NM (2015) Potential immunomodulatory effects of casein-derived bioactive peptides in human T cells. Meeting Abstract [DOI] [Details]
2015 The effect of a caseinate hydrolysate on cytokine release and RNA expression in TNF- stressed 3T3-L1 adipocytes.
O'Sullivan, SM,O'Callaghan, YC,O'Keeffe, MB,FitzGerald, RJ,O'Brien, NM (2015) The effect of a caseinate hydrolysate on cytokine release and RNA expression in TNF- stressed 3T3-L1 adipocytes. Meeting Abstract [DOI] [Details]

Professional Associations

  Association Function From / To
European Biosafety Association Member /

Education

  Year Institution Qualification Subject
2003 University of Ulster PhD Role of Microvascular Pericytes in Tumour Angiogenesis
1999 University of Ulster BSc Applied Biological and Chemical Sciences