Kieran McGourty

Lecturer Below The Bar Phd

 
researcher

Biography

Kieran McGourty is currently a lecturer below the bar in the Chemical Sciences department at the University of Limerick (UL). Kieran undertook his undergraduate studies at UL, in Industrial Biochemistry, where he worked with Dr. Jakki Cooney and Dr. Todd Kagawa. In 2006, motivated by these experiences, he went on to attain a Wellcome Trust funded PhD working with Prof. David Holden FRS, Imperial College London, studying the molecular basis of infection. During this time, Kieran published several high impact papers on the intracellular interaction of Salmonella Typhimurium with the host before changing field from cellular microbiology to cell biology.

Kieran took a post-doctoral research position in 2012 with Dr. Emmanuel Boucrot at University College London (UCL), with a primary research focus on the cell cycle and extracellular matrix (ECM) biology. Kieranís work here resulted in an extensive study into how ECM interaction evoke specific intracellular signalling profiles in quiescent cells. These findings are currently in preparation for publication.

Kieranís research aims to understand the signals that govern cell behaviour in the niche, especially the intestinal, muscular and epidermal niche. Kieran employs a number of high-throughput techniques to achieve this including; transcriptomics, phosphoproteomics, antibody signalling protein arrays and high content imaging, in addition to standard biochemical techniques.†

https://www.linkedin.com/in/mcgourtykieran
https://twitter.com/KieranMcGourty@kieranmcgourty
https://twitter.com/biosciber@biosciber

Research Interests

Kieran is one of the founding groups within the Bernal BioSciBER lab research space. The BioSciBER lab aims to carry out interdisciplinary research at the interface of Biomedical Engineering, Cell Biology and Microfluidics. They hope to reference†in vivo systems and use that knowledge to inform in vitro experimentation and medical device design in areas such as the circulatory system, stem cell niche reconstitution, blood brain barrier research and tissue mechano-characterisation.†

Specifically, Kieranís group aims to fuse biomedical engineering, ECM and cell biology to reconstitute the stem cell tissue niche in vitro by referencing and endeavouring to understand the in vivo system with a particular focus on the intestinal, muscular and epidermal niche.

Specific Research Areas

  • Stem cell differentiation
  • Stem cell niche
  • Extracellular matrix biology
  • Cell cycle
  • Intracellular trafficking
  • Cell signalling
  • Infection and immunity
  • Microbiome
  • Proteomics, transcriptomics, pathway analysis
  • Microscopy, especially high throughput imaging and confocal microscopy

†Twitter

@biosciber
@kieranmcgourty

Peer Reviewed Journals

Year Publication
2007 'HorB (HP0127) is a gastric epithelial cell adhesin'
Snelling, William J. and Moran, Anthony P. and Ryan, Kieran A. and Scully, Paul and McGourty, Kieran and Cooney, Jakki C. and Annuk, Heidi and O'Toole, Paul W. (2007) 'HorB (HP0127) is a gastric epithelial cell adhesin'. Helicobacter, 12 (3):200-209 [Details]
2010 'pH Sensing by Intracellular Salmonella Induces Effector Translocation'
Yu, Xiu-Jun and McGourty, Kieran and Liu, Mei and Unsworth, Kate E. and Holden, David W. (2010) 'pH Sensing by Intracellular Salmonella Induces Effector Translocation'. Science, 328 (5981):1040-1043 [Details]
2011 'Inhibition of apoptosis and NF-??B activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence'
de Motes, Carlos Maluquer and Cooray, Samantha and Ren, Hongwei and Almeida, Gabriel M F and McGourty, Kieran and Bahar, Mohammad W. and Stuart, David I. and Grimes, Jonathan M. and Graham, Stephen C. and Smith, Geoffrey L. (2011) 'Inhibition of apoptosis and NF-??B activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence'. PLoS Pathogens, 7 (12) [Details]
2012 'Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function'
McGourty, Kieran and Thurston, Teresa L and Matthews, Sophie a and Pinaud, Laurie and Mota, Lu\'is Jaime and Holden, David W (2012) 'Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function'. Science (New York, N.Y.), 338 (6109):963-7 [Details]
2015 'PLEKHM1 regulates salmonella-containing vacuole biogenesis and infection'
McEwan, David G. and Richter, Benjamin and Claudi, Beatrice and Wigge, Christoph and Wild, Philipp and Farhan, Hesso and McGourty, Kieran and Coxon, Fraser P. and Franz-Wachtel, Mirita and Perdu, Bram and Akutsu, Masato and Habermann, Anja and Kirchof, Anja and Helfrich, Miep H. and Odgren, Paul R. and Van Hul (2015) 'PLEKHM1 regulates salmonella-containing vacuole biogenesis and infection'. Cell Host and Microbe, 17 (1):58-71 [Details]

Other Journals

  Year Publication
2017 'Signalling mediated survival in quiescence cells'
McGourty K, Mendes-Pereira A, McMahon HT, Boucrot E (2017) 'Signalling mediated survival in quiescence cells' Under review, . [Details]
2017 'Antimyogenic TGF-β Proteins Inhibit Synaptic Function'
Augustin H, McGourty K, Boucrot E, Partridge L (2017) 'Antimyogenic TGF-β Proteins Inhibit Synaptic Function' Under review, . [Details]
2017 'Insulin Signalling Prevents Age-Related Loss of Neurotransmission by Increasing Endosomal Recycling'
Augustin H, McGourty K, Adcott J, Kerr F, Selman C, Nespital T, Tung Wong C, Allen M, Boucrot E, Partridge L. (2017) 'Insulin Signalling Prevents Age-Related Loss of Neurotransmission by Increasing Endosomal Recycling' Under review, . [Details]

Conference Contributions

  Year Publication
2009 EIMID 6th Annual Meeting,
McGourty K, (Poster) Holden DW (2009) EIMID Research Conference. [Poster Presentation], EIMID 6th Annual Meeting, Potsdam, Germany , 20-OCT-09 - 21-OCT-09 [Details]
2009 UK Membrane Trafficking Meeting,
McGourty K, (Speaker) Holden DW (2009) Annual UK Membrane Trafficking Meeting. [Oral Presentation], UK Membrane Trafficking Meeting, London, UK , 14-DEC-09 - 14-DEC-09 [Details]
2010 Wellcome Trust PhD Molecular basis of infection seminar,
McGourty K, (Speaker, Winner) Holden DW. (2010) Imperial College Wellcome Trust PhD Molecular basis of infection seminar. [Oral Presentation], Wellcome Trust PhD Molecular basis of infection seminar, London, UK , 19-MAY-10 - 19-MAY-10 [Details]
2010 Workshop: Emerging Themes in Infection Biology,
McGourty K, (Speaker) Holden DW (2010) Cellular Microbiology European Meeting. [Poster Presentation], Workshop: Emerging Themes in Infection Biology, La Colle sur Loup, France , 07-JUN-10 - 11-JUN-10 [Details]
2011 EIMID 7th Annual Meeting,
McGourty K (Speaker), Holden DW (2011) EIMID Research Conference. [Oral Presentation], EIMID 7th Annual Meeting, Sanga-Saby, Sweden , 10-OCT-11 - 13-OCT-11 [Details]
2015 Fibronectins Integrins and Related Molecules,
McGourty K, (Poster) Boucrot E. (2015) Gordon Research Conference. [Poster Presentation], Fibronectins Integrins and Related Molecules, Lucca, Italy , 03-MAY-15 - 08-MAY-15 [Details]
2016 Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar,
McGourty K, (Poster) Boucrot E. (2016) Gordon Research Seminar. [Poster Presentation], Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar, Biddeford, USA , 25-JUN-16 - 26-JUN-16 [Details]
2016 Signal Transduction by Engineered Extracellular Matrices,,
McGourty K, (Poster, Winner) Boucrot E. (2016) Gordon Research Conference. [Poster Presentation], Signal Transduction by Engineered Extracellular Matrices,, Biddeford, USA , 26-JUN-16 - 01-AUG-16 [Details]

Honours and Awards

  Year Title Awarding Body
2010 Best PhD talk winner Wellcome Trust PhD: Molecular basis of infection seminar, Imperial COllege
2016 Gordon research conference poster winner Gordon research conference: Signal Transduction by Engineered Extracellular Matrices,

Committees

  Committee Function From / To
Ethics Committee Member UL /

Employment

  Employer Position From / To
Pfizer, GE Healthcare, University College Cork, Imperial College London, University College London, University of Limerick Various /

Education

  Year Institution Qualification Subject
2007 Imperial College London PhD Cellular Microbiology: Interference with lysosomal biogenesis by Salmonella Typhimurium
2006 Imperial College London Masters by research Wellcome Trust Molecular and Cellular Basis of Infectious Disease
2001 University of Limerick BSc (Hons) Industrial Biochemistry

Languages

  Language Reading Writing Speaking
French Functional Functional Functional

Modules Taught

Term (ID)) Title Link Subject
2017 Biochemistry 2 from January 2017 Biochemistry