Kieran McGourty


Contact Details

Principal Researcher: BioSciBER labs
Analog Devices Bld.
Bernal Institute
University of Limerick
Limerick, Ireland
T: +353 61 23 7755
https://uk.linkedin.com/in/mcgourtykieran
 
researcher

Biography

Kieran McGourty is currently a lecturer below the bar in the Chemical Sciences department at the University of Limerick (UL). Kieran undertook his undergraduate studies at UL, in Industrial Biochemistry, where he worked with Dr. Jakki Cooney and Dr. Todd Kagawa. In 2006, motivated by these experiences, he went on to attain a Wellcome Trust funded PhD working with Prof. David Holden FRS, Imperial College London, studying the molecular basis of infection. During this time, Kieran published several high impact papers on the intracellular interaction of Salmonella Typhimurium with the host before changing field from cellular microbiology to cell biology.

Kieran took a post-doctoral research position in 2012 with Dr. Emmanuel Boucrot at University College London (UCL), with a primary research focus on the cell cycle and extracellular matrix (ECM) biology. Kieran’s work here resulted in an extensive study into how ECM interaction evoke specific intracellular signalling profiles in quiescent cells. These findings are currently in preparation for publication.

Kieran’s research aims to understand the signals that govern cell behaviour in the niche, especially the intestinal, muscular and epidermal niche. Kieran employs a number of high-throughput techniques to achieve this including; transcriptomics, phosphoproteomics, antibody signalling protein arrays and high content imaging, in addition to standard biochemical techniques. 

https://www.linkedin.com/in/mcgourtykieran
https://twitter.com/KieranMcGourty @kieranmcgourty
https://twitter.com/biosciber @biosciber

Research Interests

Kieran is one of the founding groups within the Bernal BioSciBER lab research space. The BioSciBER lab aims to carry out interdisciplinary research at the interface of Biomedical Engineering, Cell Biology and Microfluidics. They hope to reference in vivo systems and use that knowledge to inform in vitro experimentation and medical device design in areas such as the circulatory system, stem cell niche reconstitution, blood brain barrier research and tissue mechano-characterisation. 

Specifically, Kieran’s group aims to fuse biomedical engineering, ECM and cell biology to reconstitute the stem cell tissue niche in vitro by referencing and endeavouring to understand the in vivo system with a particular focus on the intestinal, muscular and epidermal niche.

Specific Research Areas

  • Stem cell differentiation
  • Stem cell niche
  • Extracellular matrix biology
  • Cell cycle
  • Intracellular trafficking
  • Cell signalling
  • Infection and immunity
  • Microbiome
  • Proteomics, transcriptomics, pathway analysis
  • Microscopy, especially high throughput imaging and confocal microscopy

 Twitter

@biosciber
@kieranmcgourty

Other Journals

  Year Publication
2020 'Signalling mediated survival in quiescence cells'
McGourty K, Mendes-Pereira A, McMahon HT, Boucrot E (2020) 'Signalling mediated survival in quiescence cells' Under review, . [Details]

Book Chapters

  Year Publication
2020 'Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr'
Ross, AM; Grabrucker, AM; McGourty, KD; Mulvihill, JE (2020) 'Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr' In: Sigh RW, Singh D, Kanwar J, Singh Chauha N (eds). Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 1st Edition. Cambridge, Massachusetts, United States: Academic Press. [Details]

Peer Reviewed Journals

  Year Publication
2020 'Measuring endocytosis during proliferative cell quiescence'
C Hinze, McGourty K, Boucrot E (2020) 'Measuring endocytosis during proliferative cell quiescence'. Methods in molecular biology (Clifton, N.J.), [Details]
2020 'The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions'
Connolly S.;*McGourty K.;*Newport D. *=Corresponding Author (2020) 'The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions'. Scientific Reports, 10 (1) [DOI] [Details]
2019 'Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer'
AF Mahdi, B Malacrida, J Nolan, K McGourty, AJ Lowery, PA Kiely (2019) 'Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer'. Cancer Research, 79 (13 Supplement) [Details]
2019 'Combinatorial effects of matrix stiffness and ECM proteins on cell behaviour and morphology'
S Malijauskaite, V Boomsma, C O'Connor, K McGourty (2019) 'Combinatorial effects of matrix stiffness and ECM proteins on cell behaviour and morphology'. International Journal Of Experimental Pathology, [Details]
2018 'Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer'
Amira F. Mahdi, Beatrice Malacrida, Kieran McGourty, Aoife J. Lowery and Patrick A. Kiely (2018) 'Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer'. Cancer Research, [Details]
2018 'Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster'
Augustin, H;McGourty, K;Allen, MJ;Adcott, J;Wong, CT;Boucrot, E;Partridge, L (2018) 'Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster'. Neurobiology Of Aging, 66 :149-157 [DOI] [Details]
2018 'Regional mechanical and biochemical properties of the porcine cortical meninges'
Walsh DR;Ross AM;Malijauskaite S;Flanagan BD;Newport DT;*McGourty KD;*Mulvihill JJE; * = Corresponding Author (2018) 'Regional mechanical and biochemical properties of the porcine cortical meninges'. Acta Biomaterialia, 80 [DOI] [ULIR Link] [Details]
2017 'Myostatin-like proteins regulate synaptic function and neuronal morphology'
Augustin H;McGourty K;Steinert JR;Cochemé HM;Adcott J;Cabecinha M;Vincent A;Halff EF;Kittler JT;Boucrot E;Partridge L; (2017) 'Myostatin-like proteins regulate synaptic function and neuronal morphology'. Development (Cambridge), 144 (13) [DOI] [Details]
2017 'Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies'
Augustin H;McGourty K;Allen MJ;Madem SK;Adcott J;Kerr F;Wong CT;Vincent A;Godenschwege T;Boucrot E;Partridge L; (2017) 'Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies'. Plos Biology, 15 (9) [DOI] [Details]
2015 'PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection'
McEwan DG;Richter B;Claudi B;Wigge C;Wild P;Farhan H;McGourty K;Coxon FP;Franz-Wachtel M;Perdu B;Akutsu M;Habermann A;Kirchof A;Helfrich MH;Odgren PR;Van Hul W;Frangakis AS;Rajalingam K;Macek B;Holden DW;Bumann D;Dikic I; (2015) 'PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection'. Cell Host & Microbe, 17 (1) [DOI] [Details]
2012 'Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function'
McGourty K;Thurston TL;Matthews SA;Pinaud L;Mota LJ;Holden DW; (2012) 'Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function'. Science, 338 (6109) [DOI] [Details]
2011 'Inhibition of apoptosis and NF-¿B activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence'
Maluquer de Motes C;Cooray S;Ren H;Almeida GM;McGourty K;Bahar MW;Stuart DI;Grimes JM;Graham SC;Smith GL; (2011) 'Inhibition of apoptosis and NF-¿B activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence'. Plos Pathogens, 7 (12) [DOI] [Details]
2011 'Modulation of apoptosis and pro-inflammatory signalling by vaccinia virus protein N1'
Maluquer de Motes, Carlos Cooray Samantha, Ren Hongwei, Gabriel MF Almeida, McGourty Kieran, Mohammad W Bahar, David I Stuart, Jonathan M Grimes, Stephen C Graham, Geoffrey L Smith (2011) 'Modulation of apoptosis and pro-inflammatory signalling by vaccinia virus protein N1'. Cytokine, [Details]
2010 'pH sensing by intracellular Salmonella induces effector translocation'
Yu XJ;McGourty K;Liu M;Unsworth KE;Holden DW; (2010) 'pH sensing by intracellular Salmonella induces effector translocation'. Science, 328 (5981) [DOI] [Details]
2007 'HorB (HP0127) is a gastric epithelial cell adhesin'
Snelling, WJ; Moran, AP; Ryan, KA; Scully, P; McGourty, K; Cooney, JC; Annuk, H; O'Toole, PW (2007) 'HorB (HP0127) is a gastric epithelial cell adhesin'. HELICOBACTER, 12 (3):200-209 [DOI] [Details]

Conference Contributions

  Year Publication
2009 EIMID 6th Annual Meeting,
McGourty K, (Poster) Holden DW (2009) EIMID Research Conference. [Poster Presentation], EIMID 6th Annual Meeting, Potsdam, Germany , 20-OCT-09 - 21-OCT-09 [Details]
2009 UK Membrane Trafficking Meeting,
McGourty K, (Speaker) Holden DW (2009) Annual UK Membrane Trafficking Meeting. [Oral Presentation], UK Membrane Trafficking Meeting, London, UK , 14-DEC-09 - 14-DEC-09 [Details]
2010 Wellcome Trust PhD Molecular basis of infection seminar,
McGourty K, (Speaker, Winner) Holden DW. (2010) Imperial College Wellcome Trust PhD Molecular basis of infection seminar. [Oral Presentation], Wellcome Trust PhD Molecular basis of infection seminar, London, UK , 19-MAY-10 - 19-MAY-10 [Details]
2010 Workshop: Emerging Themes in Infection Biology,
McGourty K, (Speaker) Holden DW (2010) Cellular Microbiology European Meeting. [Poster Presentation], Workshop: Emerging Themes in Infection Biology, La Colle sur Loup, France , 07-JUN-10 - 11-JUN-10 [Details]
2011 EIMID 7th Annual Meeting,
McGourty K (Speaker), Holden DW (2011) EIMID Research Conference. [Oral Presentation], EIMID 7th Annual Meeting, Sanga-Saby, Sweden , 10-OCT-11 - 13-OCT-11 [Details]
2015 Fibronectins Integrins and Related Molecules,
McGourty K, (Poster) Boucrot E. (2015) Gordon Research Conference. [Poster Presentation], Fibronectins Integrins and Related Molecules, Lucca, Italy , 03-MAY-15 - 08-MAY-15 [Details]
2016 Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar,
McGourty K, (Poster) Boucrot E. (2016) Gordon Research Seminar. [Poster Presentation], Signal Transduction by Engineered Extracellular Matrices, Gordon Research Seminar, Biddeford, USA , 25-JUN-16 - 26-JUN-16 [Details]
2016 Signal Transduction by Engineered Extracellular Matrices,,
McGourty K, (Poster, Winner) Boucrot E. (2016) Gordon Research Conference. [Poster Presentation], Signal Transduction by Engineered Extracellular Matrices,, Biddeford, USA , 26-JUN-16 - 01-AUG-16 [Details]

Honours and Awards

  Year Title Awarding Body
2010 Best PhD talk winner Wellcome Trust PhD: Molecular basis of infection seminar, Imperial COllege
2016 Gordon research conference poster winner Gordon research conference: Signal Transduction by Engineered Extracellular Matrices,

Committees

  Committee Function From / To
Ethics Committee Member UL /

Employment

  Employer Position From / To
Pfizer, GE Healthcare, University College Cork, Imperial College London, University College London, University of Limerick Various /

Education

  Year Institution Qualification Subject
2007 Imperial College London PhD Cellular Microbiology: Interference with lysosomal biogenesis by Salmonella Typhimurium
2006 Imperial College London Masters by research Wellcome Trust Molecular and Cellular Basis of Infectious Disease
2001 University of Limerick BSc (Hons) Industrial Biochemistry

Languages

  Language Reading Writing Speaking
French Functional Functional Functional

Modules Taught

  Term (ID)) Title Link Subject
2017 Biochemistry 2 from January 2017 Biochemistry