Ciolino, JB; Hudson, SP; Mobbs, AN; Hoare, TR; Iwata, NG; Fink, GR; Kohane, DS

2011

January

Investigative Ophthalmology & Visual Science

A Prototype Antifungal Contact Lens

Published

()

FUNGAL KERATITIS DRUG-DELIVERY MANAGEMENT FUSARIUM SUSCEPTIBILITY GANCICLOVIR TEMPERATURE ECONAZOLE OUTBREAK

52

6286

6291

PURPOSE. To design a contact lens to treat and prevent fungal ocular infections.METHODS. Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37 degrees C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.RESULTS. Econazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens.CONCLUSIONS. An econazole-eluting contact lens could be used as a treatment for fungal ocular infections. (Invest Ophthalmol Vis Sci. 2011;52:6286-6291) DOI:10.1167/iovs.10-6935

10.1167/iovs.10-6935