Robin, S,Gandhi, AA,Gregor, M,Laffir, FR,Pecenik, T,Pecenik, A,Soulimane, T,Tofail, SAM

2011

January

Langmuir

Charge Specific Protein Placement at Submicrometer and Nanometer Scale by Direct Modification of Surface Potential by Electron Beam

Published

()

SYNTHETIC CALCIUM HYDROXYAPATITES ADSORPTION LYSOZYME ADHESION LITHOGRAPHY WETTABILITY

27

14968

14974

The understanding and the precise control of protein adsorption is extremely important for the development and optimization of biomaterials. The challenge resides in controlling the different surface properties, such as surface chemistry, roughness, wettability, or surface charge, independently, as modification of one property generally affects the other. We demonstrate the creation of electrically modified patterns on hydroxyapatite by using scanning electron beam to tailor the spatial regulation of protein adsorption via electrostatic interactions without affecting other surface properties of the material. We show that domains, presenting modulated surface potential, can be created to precisely promote or reduce protein adsorption.

10.1021/la203491q