Peer-Reviewed Journal Details
Mandatory Fields
Macchi, EG,Tosi, D,Braschi, G,Gallati, M,Cigada, A,Busca, G,Lewis, E
Journal Of Biomedical Optics
Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution
Optional Fields
fiber optic sensors distributed temperature sensor radiofrequency thermal ablation ex vivo liver tissue Rayleigh backscattering THERMAL ABLATION CANCER LIVER THERAPY
Radiofrequency thermal ablation (RFTA) induces a high-temperature field in a biological tissue having steep spatial (up to 6 degrees C/mm) and temporal (up to 1 degrees C/s) gradients. Applied in cancer care, RFTA produces a localized heating, cytotoxic for tumor cells, and is able to treat tumors with sizes up to 3 to 5 cm in diameter. The online measurement of temperature distribution at the RFTA point of care has been previously carried out with miniature thermocouples and optical fiber sensors, which exhibit problems of size, alteration of RFTA pattern, hysteresis, and sensor density worse than 1 sensor/cm. In this work, we apply a distributed temperature sensor (DTS) with a submillimeter spatial resolution for the monitoring of RFTA in porcine liver tissue. The DTS demodulates the chaotic Rayleigh backscattering pattern with an interferometric setup to obtain the real-time temperature distribution. A measurement chamber has been set up with the fiber crossing the tissue along different diameters. Several experiments have been carried out measuring the space-time evolution of temperature during RFTA. The present work showcases the temperature monitoring in RFTA with an unprecedented spatial resolution and is exportable to in vivo measurement; the acquired data can be particularly useful for the validation of RFTA computational models. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Grant Details