Kolaj-Robin, O,Russell, D,Hayes, KA,Pembroke, JT,Soulimane, T

2015

May

Febs Letters

Cation Diffusion Facilitator family: Structure and function

Published

()

Cation Diffusion Facilitator Membrane protein Zinc transporter Maricaulis maris ZINC TRANSPORTER YIIP METAL TOLERANCE PROTEINS ESCHERICHIA-COLI SACCHAROMYCES-CEREVISIAE ARABIDOPSIS-THALIANA CRYSTAL-STRUCTURE STAPHYLOCOCCUS-AUREUS THERMUS-THERMOPHILUS METALLIDURANS CH34 ANTIPORT MECHANISM

1283

1295

The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn2+ and Cd2+ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

10.1016/j.febslet.2015.04.007