The purpose of this audit was to provide empirical evidence for the outcomes of care of advanced nurse practitioners (ANPs) within the emergency department (ED). In addition, the audit permitted the comparison of ANPs with other medical clinicians working in the ED setting in relation to results of radiology investigations, analgesia administration, and waiting times. Results show that ANPs have equivalent if not better radiology diagnostic skills, evidence of increased awareness of pain management practices, and a greater impact on reducing patient waiting times compared to other grades of clinician.