Peer-Reviewed Journal Details
Mandatory Fields
Jakeman, P. M.,Hawthorne, J. E.,Maxwell, S. R.,Kendall, M. J.,Holder, G.
1994
May
Exp Physiolexp Physiol
Evidence for downregulation of hypothalamic 5-hydroxytryptamine receptor function in endurance-trained athletes
Published
()
Optional Fields
Adult *Down-Regulation Humans Hypothalamus/*metabolism Male Osmolar Concentration *Physical Endurance Prolactin/blood Receptors, Serotonin/*metabolism Reference Values
79
33
461
4
Serum prolactin (PRL) was used as a hormone marker of serotoninergic function following oral administration of an acute dose of a serotoninergic agonist. Five male endurance-trained athletes (ET) and five healthy non-endurance-trained controls (NT) were studied. The peak PRL concentration was lower (P = 0.031) for the ET athletes (486 +/- 208 mU l-1; mean +/- S.D.) than for the NT controls (1000 +/- 385 mU l-1); the total release of PRL was also lower (P = 0.042) for the ET subjects. The lower neuroendocrine response to a serotoninergic agonist in the endurance-trained athletes suggests a downregulation of central serotoninergic receptor function in response to endurance training in man.Serum prolactin (PRL) was used as a hormone marker of serotoninergic function following oral administration of an acute dose of a serotoninergic agonist. Five male endurance-trained athletes (ET) and five healthy non-endurance-trained controls (NT) were studied. The peak PRL concentration was lower (P = 0.031) for the ET athletes (486 +/- 208 mU l-1; mean +/- S.D.) than for the NT controls (1000 +/- 385 mU l-1); the total release of PRL was also lower (P = 0.042) for the ET subjects. The lower neuroendocrine response to a serotoninergic agonist in the endurance-trained athletes suggests a downregulation of central serotoninergic receptor function in response to endurance training in man.
0958-0670 (Print) 0958-06
1994/05/01
http://onlinelibrary.wiley.com/store/10.1113/expphysiol.1994.sp003780/asset/eph1994793461.pdf?v=1&t=ieya15q6&s=963df3588f2780a1bfaec57ab7471fdc13cdfafehttp://onlinelibrary.wiley.com/store/10.1113/expphysiol.1994.sp003780/asset/eph1994793461.pdf?v=1&t=ieya
Grant Details