Peer-Reviewed Journal Details
Mandatory Fields
Pembroke, JT,Quinn, L,O'Riordan, H,Sheahan, C,Armshaw, P,Los, DA
2017
January
Cyanobacteria: Omics And Manipulation
Ethanol Production in Cyanobacteria: Impact of Omics of the Model Organism Synechocystis on Yield Enhancement
Published
()
Optional Fields
SP PCC 6803 PYRUVATE DECARBOXYLASE GENE ZYMOMONAS-MOBILIS ESCHERICHIA-COLI SP PCC6803 LACTIC-ACID PHOTOSYNTHETIC PRODUCTION SP PCC-6803 ALCOHOL-DEHYDROGENASE SYNTHETIC BIOLOGY
199
217
     Due to their phototrophic lifestyle, cyanobacteria have been investigated as a sustainable source of biofuel production. Model cyanobacteria, such as Synechocystis, have been metabolically engineered with heterologous genes encoding pyruvate decarboxylase and alcohol dehydrogenase to convert the metabolic intermediate pyruvate first to acetaldehyde and then to ethanol. The current state of the art suggests that there is some way to go before such a system can be exploited. Lessons from the genomics of the model organism and proteomic and transcriptomic analysis of the organism's response to ethanol production are being utilised to enhance productivity. These are informing a systems approach to rational modification for enhanced ethanol production, which will be a key to the biotechnological exploitation of such a system.                                               
Caister Academic Press
ISBN: 978-1-910190-55-5
https://www.caister.com/cyano3
DOI: https://doi.org/10.21775/9781910190555
Grant Details