Peer-Reviewed Journal Details
Mandatory Fields
Viphavakit, C,O'Keeffe, S,Yang, MH,Andersson-Engels, S,Lewis, E
Journal Of Lightwave Technology
Gold Enhanced Hemoglobin Interaction in a Fabry-Perot Based Optical Fiber Sensor for Measurement of Blood Refractive Index
Optional Fields
Fabry-Perot interferometer optical fiber sensor refractive index sensing O2 TENSION MEASUREMENTS TUMOR HYPOXIA OXYGENATION CANCER NANOPARTICLES THERAPY PO-2
A Fabry-Perot based optical fiber sensor to measure the oxygen concentration through monitoring the change of refractive index in red blood cells is reported. The optical fiber sensor with a diameter of 220 mu m is made entirely of fused silica glass fibers, which can be integrated within standard brachytherapy seed delivery needle to be used in vivo. Isopropanol solution and pig blood are prepared to produce refractive index in the range 1.344-1.365. Gold is coated to a thickness of 100 nm at the tip of the sensor to enhance the interaction between hemoglobin and light. A fast Fourier transform algorithm is used to analyze the phase angle from the reflected output spectrum. The gold-coated sensor has up to almost ten times higher sensitivity to hemoglobin concentration in blood solutions compared to isopropanol solutions. A sensitivity of 9.82 rad/RIU with a refractive index resolution of 2.09 x 10(-3) RIU is achieved for the sensor with a 16 mu m thickness diaphragm.
Grant Details