Peer-Reviewed Journal Details
Mandatory Fields
Karimi-Jafari, M;Padrela, L;Walker, GM;Croker, DM
2018
October
Crystal Growth & Design
Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
Published
203 ()
Optional Fields
HOT-MELT EXTRUSION INDOMETHACIN-SACCHARIN COCRYSTALS NEAR-INFRARED SPECTROSCOPY TWIN-SCREW EXTRUSION CO-CRYSTALS SOLID-STATE MECHANICAL-PROPERTIES PHYSICOCHEMICAL PROPERTIES ACID COCRYSTAL SCALE-UP
18
6370
6387
Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals. Intensification of cocrystal research efforts has been accompanied by an expansion of the potential applications where cocrystals can offer a benefit. Where once solubility manipulation was seen as the primary driver for cocrystal formation, cocrystals have recently been shown to provide attractive options for taste masking, mechanical property improvement, and intellectual property generation and extension. Cocrystals are becoming a commercial reality with a number of cocrystal products currently on the market and more following in registration and clinical trial phases. Increased commercialization of cocrystals has in turn necessitated additional research on methods to make cocrystals, with particular emphasis placed on emerging technologies that can offer environmentally attractive and efficient options. Methods of producing cocrystals and of harnessing the bespoke physical property adjustment provided by cocrystals are reviewed in this article, with a particular focus on emerging trends in these areas.
WASHINGTON
1528-7483
10.1021/acs.cgd.8b00933
Grant Details