Peer-Reviewed Journal Details
Mandatory Fields
Augustin, H;McGourty, K;Allen, MJ;Adcott, J;Wong, CT;Boucrot, E;Partridge, L
2018
June
Neurobiology Of Aging
Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster
Published
0 ()
Optional Fields
CENTRAL-NERVOUS-SYSTEM LIFE-SPAN EXTENSION AGE-RELATED-CHANGES GIANT FIBER SYSTEM ALZHEIMERS-DISEASE PROTEIN HOMEOSTASIS FLIGHT INITIATIONS SYNAPSE FORMATION OXIDATIVE STRESS GROWTH
66
149
157
The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging. (C) 2018 Elsevier Inc.
NEW YORK
0197-4580
10.1016/j.neurobiolaging.2018.02.027
Grant Details