Peer-Reviewed Journal Details
Mandatory Fields
Tsoupras, A;Lordan, R;Zabetakis, I
2018
May
Nutrients
Inflammation, not Cholesterol, Is a Cause of Chronic Disease
Published
12 ()
Optional Fields
PLATELET-ACTIVATING-FACTOR BREAM SPARUS-AURATA BASS DICENTRARCHUS-LABRAX CORONARY-HEART-DISEASE HIV-INFECTED PATIENTS RANDOMIZED CONTROLLED-TRIAL MEDITERRANEAN DIETARY PATTERN ACTIVE ANTIRETROVIRAL THERAPY SYSTEMIC-LUPUS-ERYTHEMATOSUS FUTURE CLINICAL-IMPLICATIONS
10
Since the Seven Countries Study, dietary cholesterol and the levels of serum cholesterol in relation to the development of chronic diseases have been somewhat demonised. However, the principles of the Mediterranean diet and relevant data linked to the examples of people living in the five blue zones demonstrate that the key to longevity and the prevention of chronic disease development is not the reduction of dietary or serum cholesterol but the control of systemic inflammation. In this review, we present all the relevant data that supports the view that it is inflammation induced by several factors, such as platelet-activating factor (PAF), that leads to the onset of cardiovascular diseases (CVD) rather than serum cholesterol. The key to reducing the incidence of CVD is to control the activities of PAF and other inflammatory mediators via diet, exercise, and healthy lifestyle choices. The relevant studies and data supporting these views are discussed in this review.
BASEL
2072-6643
10.3390/nu10050604
Grant Details