Peer-Reviewed Journal Details
Mandatory Fields
Prokopowicz, M;Zeglinski, J;Szewczyk, A;Skwira, A;Walker, G
2019
January
Aaps Pharmscitech
Surface-Activated Fibre-Like SBA-15 as Drug Carriers for Bone Diseases
Published
9 ()
Optional Fields
MESOPOROUS SILICA NANOPARTICLES IN-VITRO CHARACTERIZATION SUSTAINED-RELEASE DELIVERY SYSTEMS PH HYDROXYAPATITE ADSORPTION NANOMATERIALS MICROCAPSULES REGENERATION
20
Here, we report an inorganic hexagonally ordered mesoporous fibre-like carrier made of silica as an effective drug delivery system with mineralisation potential. Fibre-like SBA-15 has been modified by employing a simple surface activation (rehydroxylation) procedure. The surface-rehydroxylated fibre-like SBA-15 (SBA-15-R) was used to investigate the possible mechanism of hydroxyapatite (HA) nucleation and deposition onto silica's surface after immersion in simulated body fluid (SBF). Amorphous calcium phosphate, Ca-deficient HA and bone-like HA deposits were observed on SBA-15-R surface consecutively after 7, 14 and 21days of immersion in SBF. Accordingly, our low-angle XRD, STEM and N-2 adsorption/desorption results indicated that deposited ions were mostly located at the silica's surface and could modify the size of the mesopores. The SBA-15-R was studied in vitro as the potential bioactive drug delivery system using doxorubicin (DOX) as a model water-soluble and anticancer drug. The adsorbed DOX molecules were mostly located at the pore walls and pore openings, likely together with the silanol groups. The DOX release was diffusion-controlled and relatively slower in SBF (pH=7.4) than in phosphate-buffered solution (pH=5.0), most probably due to both the stronger electrostatic interactions occurring between the DOX and the SBA-15-R and the simultaneous deposition of calcium and phosphates ions from SBF.
NEW YORK
1530-9932
10.1208/s12249-018-1243-5
Grant Details