Peer-Reviewed Journal Details
Mandatory Fields
Sioriki, E;Lordan, R;Nahra, F;van Hecke, K;Zabetakis, I;Nolan, SP
2018
December
Chemmedchem
In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds
Published
0 ()
Optional Fields
PLATELET-ACTIVATING-FACTOR FACTOR PAF RECEPTOR POTENT INFLAMMATION ANTAGONIST HISTAMINE DISEASE ATHEROSCLEROSIS METASTASIS
13
2484
2487
The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC center dot H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*center dot H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
WEINHEIM
1860-7179
10.1002/cmdc.201800601
Grant Details