Computer technologies, especially ICTs (Information and Communication Technologies), have become ubiquitous in people's lives. Nowadays, mobile phones, PDAs, laptops and a constellation of software applications are more and more used for a variety of activities carried out in both personal and professional lives. Given the features that these technologies provide and are provided with, for example, connectivity and portability, it can be said that ICTs have the potential to support nomadic work practices which are seen as increasingly characteristic of the knowledge economy. This chapter presents a review of the concept of nomadic work and, based on a broad literature analysis, discusses the ways in which ICTs may empower people who are involved with nomadic work practices. It aims to give a starting point for those who intend to develop further research on technologically-mediated nomadic work practices in the knowledge economy. © 2011, IGI Global.