Romero, J.,Muniz, J.,Logica Tornatore, T.,Holubiec, M.,Gonzalez, J.,Barreto, G. E.,Guelman, L.,Lillig, C. H.,Blanco, E.,Capani, F.

2014

April

Neurosci Lettneurosci Lett

Dual role of astrocytes in perinatal asphyxia injury and neuroprotection

Published

()

Animals Asphyxia Neonatorum/*pathology Astrocytes/pathology/*physiology Humans

565

42

6

Perinatal asphyxia represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness. However, at the moment, most of the therapeutic strategies were not well targeted toward the processes that induced the brain injury during perinatal asphyxia. Traditionally, experimental research focused on neurons, whereas astrocytes have been more related with the damage mechanisms of perinatal asphyxia. In this work, we propose to review possible protective as well as deleterious roles of astrocytes in the asphyctic brain with the aim to stimulate further research in this area of perinatal asphyxia still not well studied.Perinatal asphyxia represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness. However, at the moment, most of the therapeutic strategies were not well targeted toward the processes that induced the brain injury during perinatal asphyxia. Traditionally, experimental research focused on neurons, whereas astrocytes have been more related with the damage mechanisms of perinatal asphyxia. In this work, we propose to review possible protective as well as deleterious roles of astrocytes in the asphyctic brain with the aim to stimulate further research in this area of perinatal asphyxia still not well studied.

1872-7972 (Electronic) 03

2013/11/01

http://www.ncbi.nlm.nih.gov/pubmed/24172702http://www.ncbi.nlm.nih.gov/pubmed/24172702

10.1016/j.neulet.2013.10.046