Peer-Reviewed Journal Details
Mandatory Fields
Gonzalez-Giraldo, Y.,Forero, D. A.,Echeverria, V.,Gonzalez, J.,Avila-Rodriguez, M.,Garcia-Segura, L. M.,Barreto, G. E.
2016
July
Ageing Res Revageing Res Rev
Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system
Published
()
Optional Fields
Aging/*drug effects/genetics Animals Central Nervous System/metabolism DNA Damage Humans Neurodegenerative Diseases/*drug therapy/genetics Neuroprotective Agents/*therapeutic use Oxidative Stress/physiology Reactive Oxygen Species/metabolism Telomerase/genetics/metabolism/*therapeutic use Telomere/metabolism Telomere Shortening
28
37
45
Senescence plays an important role in neurodegenerative diseases and involves key molecular changes induced by several mechanisms such as oxidative stress, telomere shortening and DNA damage. Potential therapeutic strategies directed to counteract these molecular changes are of great interest for the prevention of the neurodegenerative process. Telomerase is a ribonucleoprotein composed of a catalytic subunit (TERT) and a RNA subunit (TERC). It is known that the telomerase is involved in the maintenance of telomere length and is a highly expressed protein in embryonic stages and decreases in adult cells. In the last decade, a growing number of studies have shown that TERT has neuroprotective effects in cellular and animal models after a brain injury. Significantly, differences in TERT expression between controls and patients with major depressive disorder have been observed. More recently, TERT has been associated with the decrease in reactive oxygen species and DNA protection in mitochondria of neurons. In this review, we highlight the role of TERT in some neurodegenerative disorders and discuss some studies focusing on this protein as a potential target for neuroprotective therapies.Senescence plays an important role in neurodegenerative diseases and involves key molecular changes induced by several mechanisms such as oxidative stress, telomere shortening and DNA damage. Potential therapeutic strategies directed to counteract these molecular changes are of great interest for the prevention of the neurodegenerative process. Telomerase is a ribonucleoprotein composed of a catalytic subunit (TERT) and a RNA subunit (TERC). It is known that the telomerase is involved in the maintenance of telomere length and is a highly expressed protein in embryonic stages and decreases in adult cells. In the last decade, a growing number of studies have shown that TERT has neuroprotective effects in cellular and animal models after a brain injury. Significantly, differences in TERT expression between controls and patients with major depressive disorder have been observed. More recently, TERT has been associated with the decrease in reactive oxygen species and DNA protection in mitochondria of neurons. In this review, we highlight the role of TERT in some neurodegenerative disorders and discuss some studies focusing on this protein as a potential target for neuroprotective therapies.
1872-9649 (Electronic) 15
2016/04/21
http://www.ncbi.nlm.nih.gov/pubmed/27095058http://www.ncbi.nlm.nih.gov/pubmed/27095058
10.1016/j.arr.2016.04.004
Grant Details