Peer-Reviewed Journal Details
Mandatory Fields
Mendoza, C.,Barreto, G. E.,Avila-Rodriguez, M.,Echeverria, V.
2016
October
Mol Cell Endocrinolmol Cell Endocrinol
Role of neuroinflammation and sex hormones in war-related PTSD
Published
()
Optional Fields
Female Gonadal Steroid Hormones/*metabolism Humans Immunity, Innate Male Sex Factors Stress Disorders, Post-Traumatic/etiology/*metabolism/*psychology Stress, Psychological/*immunology Warfare
434
266
77
The susceptibility to develop posttraumatic stress disorder (PTSD) is greatly influenced by both innate and environmental risk factors. One of these factors is gender, with women showing higher incidence of trauma-related mental health disorders than their male counterparts. The evidence so far links these differences in susceptibility or resilience to trauma to the neuroprotective actions of sex hormones in reducing neuroinflammation after severe stress exposure. In this review, we discuss the impact of war-related trauma on the incidence of PTSD in civilian and military populations as well as differences associated to gender in the incidence and recovery from PTSD. In addition, the mutually influencing role of inflammation, genetic, and sex hormones in modulating the consequences derived from exposure to traumatic events are discussed in light of current evidence.The susceptibility to develop posttraumatic stress disorder (PTSD) is greatly influenced by both innate and environmental risk factors. One of these factors is gender, with women showing higher incidence of trauma-related mental health disorders than their male counterparts. The evidence so far links these differences in susceptibility or resilience to trauma to the neuroprotective actions of sex hormones in reducing neuroinflammation after severe stress exposure. In this review, we discuss the impact of war-related trauma on the incidence of PTSD in civilian and military populations as well as differences associated to gender in the incidence and recovery from PTSD. In addition, the mutually influencing role of inflammation, genetic, and sex hormones in modulating the consequences derived from exposure to traumatic events are discussed in light of current evidence.
1872-8057 (Electronic) 03
2016/05/25
http://www.ncbi.nlm.nih.gov/pubmed/27216917http://www.ncbi.nlm.nih.gov/pubmed/27216917
10.1016/j.mce.2016.05.016
Grant Details