Mazo, N. A.,Echeverria, V.,Cabezas, R.,Avila-Rodriguez, M.,Tarasov, V. V.,Yarla, N. S.,Aliev, G.,Barreto, G. E.

2017

Curr Pharm Descurr Pharm Des

Medicinal Plants as Protective Strategies Against Parkinson's Disease

Published

()

Animals Antioxidants/metabolism/pharmacology Antiparkinson Agents/isolation & purification/pharmacology Dopaminergic Neurons/metabolism Free Radicals/metabolism Humans Neuroprotective Agents/isolation & purification/pharmacology Oxidative Stress/drug effects Parkinson Disease/physiopathology/*prevention & control Plant Preparations/chemistry/*pharmacology Plants, Medicinal/*chemistry Reactive Oxygen Species/metabolism

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Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-kappaB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds.Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-kappaB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds.

1873-4286 (Electronic) 13

2017/03/18

http://www.ncbi.nlm.nih.gov/pubmed/28302024http://www.ncbi.nlm.nih.gov/pubmed/28302024

10.2174/1381612823666170316142803