A growing body of research suggests that inequality can be stressful for all within a society. We consider this assertion by exploring whether there is evidence of physiological stress responses to different income and inequality conditions in a hypothetical society. The combined effect of inequality for different income groups on cardiovascular reactivity was assessed while participants engaged in purchasing decisions. The study included 102 participants, 84 of which had full data for analyses (42 male, 41 female, 1 unspecified). The average age was 23 years. A 3 x 2 design manipulated both inequality (stable, increasing, and decreasing) and income (high and low). Cardiovascular reactivity was operationalized as change in heart rate (HR) and blood pressure (BP; diastolic and systolic) responses at the end of the purchasing task compared with baseline. Although there was no direct association between income, inequality, and BP, results indicated that low-income participants had the higher HR reactivity to stable inequality compared with increasing inequality. These findings indicate that inequality has the hallmarks of a stressor; this is contingent on the type of inequality. This suggests that inequality itself may be detrimental to future health via the stress pathway. These findings highlight that the nature of inequality, increasing, decreasing, or stable is relevant to its impact and that these impacts of inequality may extend to the biological.