Background: Ostomy formation is life-changing surgery, and patient numbers are increasing globally. Knowledge of stoma care and management among nurses in acute settings is vital to provide holistic care, support patients' return to normal life and prevent complications. Aim: To estimate the knowledge of stoma care among nurses working in acute settings using an integrative review. Method: Five databases were searched between 2009 and 2020. A methodological approach for integrative reviews and a thematic analysis framework were used to identify themes from 10 papers. Reporting followed PRISMA guidelines, and quality appraisal was conducted. Findings: Nurses working in acute care settings have limited knowledge of stoma care, and confidence in care provision to patients with ostomies is affected by a lack of exposure. Confusion exists regarding the responsibilities of nurses when stoma care is required for an inpatient. Conclusion: Knowledge deficits regarding stoma care need to be addressed via exposure and support to deliver stoma care, access to evidence-based policies and protocols and clear referral pathways.