This study investigates chronic conditions (CC) prevalence among children in mainstream schools, their school experience and life satisfaction in Europe. Data were collected from the 2017/2018 HBSC survey, a cross-national study using self-reported questionnaires administered in classrooms. Nationally representative samples of children aged 11, 13, and 15 years in mainstream schools from 19 European countries (n = 104,812) were used. School experience was assessed using four variables: low school satisfaction, schoolwork pressure, low teacher support, and peer-victimization, which were related to life satisfaction. Latent class analysis (LCA) was conducted to identify patterns of school experience among students with CC. The prevalence of CC varied from 8.4 (Armenia) to 28.2% (Finland). Children with CC (n = 17,514) rated their school experience and life satisfaction lower than children without CC. LCA identified three school experience patterns: ¿negative on all items¿ (37%), ¿negative on all items, except school pressure¿ (40%) and ¿overall positive¿ (23%). The distribution of subgroups varied across countries¿in countries with a higher proportion of children with CC in mainstream schools, children reported more negative school experiences. Compared to the ¿overall positive¿ group, low life satisfaction was highest for students classified as ¿negative on all items¿ (relative risk (RR) = 2.9; 95% CI 2.2¿3.8) with a lesser effect for ¿negative on all items, except school pressure¿ (RR) = 1.8; 95% CI 1.4¿2.4). These findings provide cross-national data documenting the diversity in inclusive educational practices regarding school placement and school experiences, and suggest that efforts are still needed to allow a fully inclusive environment.