Andreas Grabrucker


 
researcher

Biography

CAREER PROFILE

Education 
  • 2000-2005  TU Munich, Germany, Diploma in Biology, Major: Genetics, Minor: Neurobiology and Zoology
  • 2005-2009   University Ulm, Germany, PhD, international PhD program in molecular medicine 

Employment
  • 2009-2011 Postdoctoral fellow, Stanford University, USA, Dept. of Psychiatry and Behavioral Sciences, Stanford School of Medicine
  • 2011-2016 Assistant Professor, University Ulm, Germany, Dept. of Neurology
  • 2011-2016 Executive Director of the Neurocenter of Ulm University   
  • 2017-         Lecturer in Cell Biology, University of Limerick, Ireland, Dept. of Biological Sciences, School of Natural Sciences

Scientific Activities - My research focuses on synaptopathies as a key feature of neurodevelopmental diseases. Disruptions in synaptic structure leading to abnormal circuit formation and function are potentially the major determinant of such brain diseases. My work aims to understand how genetic and non-genetic factors contribute to neuronal dysfunction and to develop novel research and treatment strategies using nanotechnology.    

Research Interests

My research is interested in the underlying components able to modify synaptic plasticity and transmission in the Central Nervous System (CNS) in health and disease. Thereby, synaptopathy defines key features of neurodegenerative and psychiatric diseases. It implies that disruptions in synaptic structure and function are potentially the major determinant of such brain diseases.
Using a combination of biochemical, cellular, molecular and behavioral approaches, we have investigated proteins of excitatory postsynapses focusing on their deregulation in neurodevelopmental and neuropsychiatric disorders such as Autism Spectrum Disorders, Alzheimer’s disease and Schizophrenia. We are especially interested in the functional interaction of biometals and synaptic proteins in mechanisms such as synapse formation and maturation in health and disease. Given that dysregulation of trace metals is reported in many brain disorders, their role in the modification of synaptic function needs to be investigated in more detail. Especially since many brain disorders seem to not only have a genetic but also an environmental component triggering the disease. To investigate the role of biometals in disorders of the CNS, we use several approaches. For example, targeted manipulation of biometal levels in animal models and cells derived from human induced pluripotent stem cells is a major goal in our research. To that end, the development of novel drug carriers (i.e. Nanoparticles) and assays designed to evaluate their potency to influence synapse formation, maturation and plasticity has become an important part of our research. On the other hand, we investigate human patients with selected disorders and perform a state of the art assessment of their trace metal status and clinical phenotype to define subgroups with biometal abnormalities, which can be associated with specific clinical presentations. Understanding how environmental and genetic factors contribute to synaptic function will hopefully allow the development of research strategies to normalize function in individuals with synaptopathies.   

Books

  Year Publication
2019 Eco-Neurobiology and how the environment shapes our brain.
Andreas M. Grabrucker (2019) Eco-Neurobiology and how the environment shapes our brain. Newcastle upon Tyne, UK: Cambridge Scholars. [Details]

Book Chapters

  Year Publication
2020 'Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases'
Joana S. Cristóvão, Guilherme G. Moreira, Andreas M. Grabrucker, Cláudio M. Gomes (2020) 'Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases' In: Angel L. Pey (eds). Protein Homeostasis Diseases. Amsterdam, NL: Elsevier. [DOI] [Details]
2020 'Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr'
Ross, AM; Grabrucker, AM; McGourty, KD; Mulvihill, JE (2020) 'Chapt 9: Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barr' In: Sigh RW, Singh D, Kanwar J, Singh Chauha N (eds). Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 1st Edition. Cambridge, Massachusetts, United States: Academic Press. [Details]
2019 'The Role of Trace Metals in Alzheimer’s Disease'
Chiara A. De Benedictis, Antonietta Vilella, Andreas M. Grabrucker (2019) 'The Role of Trace Metals in Alzheimer’s Disease' In: Thomas Wisniewski (eds). Alzheimer's Disease. Brisbane, Australia: Codon Publications. [DOI] [Details]
2017 'Animal models of ASD – Extracerebral dysfunction'
Hill-Yardin, EL; McKeown, SJ; Novarino, G; Grabrucker, AM (2017) 'Animal models of ASD – Extracerebral dysfunction' In: Advances in Anatomy, Embryology and Cell Biology, Translational anatomy and cell biology of autism spectrum disorders. Germany: Springer Nature. [DOI] [Details]
2017 'Zinc and autism'
Grabrucker, S; Grabrucker AM (2017) 'Zinc and autism' In: Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics. Netherlands: Elsevier. [Details]
2017 'Neurodegenerative Diseases: Anatomy and Pathology'
Sarowar, T; Grabrucker, AM (2017) 'Neurodegenerative Diseases: Anatomy and Pathology' In: Frontiers in Nanomedicine: Nanomedicine and Neuroscience. Sharjah: Bentham Science Publishers. [Details]
2016 'Zinc in the developing brain'
Grabrucker, AM (2016) 'Zinc in the developing brain' In: Nutrition and the developing brain. USA: CRC Press. [Details]
2016 'Zinc Deficiency'
Sauer, AK; Hagmeyer, S; Grabrucker, AM (2016) 'Zinc Deficiency' In: Nutritional Deficiency. Croatia: InTech. [DOI] [Details]
2014 'Ursachen'
Grabrucker, AM; Schmeisser, MJ (2014) 'Ursachen' In: Handlexikon Autismus-Spektrum: Schlüsselbegriffe aus Forschung, Theorie, Praxis und Betroffenen-Sicht. Germany: Kohlhammer. [Details]
2013 'Nanoparticles as Blood–Brain Barrier Permeable CNS Targeted Drug Delivery Systems'
Grabrucker, AM; Chhabra, R; Belletti, D; Forni, F; Vandelli, MA; Ruozi, B; Tosi,G (2013) 'Nanoparticles as Blood–Brain Barrier Permeable CNS Targeted Drug Delivery Systems' In: Topics in Medicinal Chemistry. Germany: Springer. [DOI] [Details]

Peer Reviewed Journals

  Year Publication
2020 'Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles'
Lutz AK;Pfaender S;Incearap B;Ioannidis V;Ottonelli I;Föhr KJ;Cammerer J;Zoller M;Higelin J;Giona F;Stetter M;Stoecker N;Alami NO;Schön M;Orth M;Liebau S;Barbi G;Grabrucker AM;Delorme R;Fauler M;Mayer B;Jesse S;Roselli F;Ludolph AC;Bourgeron T;Verpelli C;Demestre M;Boeckers TM; (2020) 'Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles'. Science Translational Medicine, 12 (547) [DOI] [Details]
2020 'Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers'
Mulvihill J.;Cunnane E.;Ross A.;Duskey J.;Tosi G.;Grabrucker A. (2020) 'Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers'. Nanomedicine (London, England), 15 (2):205-214 [DOI] [ULIR Link] [Details]
2020 'Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties'
Ross A.M.;Kennedy T.;McNulty D.;Leahy C.I.;Walsh D.R.;Murray P.;Grabrucker A.M.;Mulvihill J.J.E. (2020) 'Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties'. Materials Science & Engineering C-Materials For Biological Applications, 113 [DOI] [ULIR Link] [Details]
2020 'Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment'
Oddone N, Boury F, Garcion E, Grabrucker AM, Del Carmen Martinez M, Da F, Janaszewska A, Forni F, Vandelli MA, Tosi G, Ruozi B, Duskey JT (2020) 'Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment'. Frontiers In Pharmacology, 11 (574) [DOI] [Details]
2019 'Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives'
Ross AM;Mc Nulty D;O'Dwyer C;Grabrucker AM;Cronin P;Mulvihill JJE; (2019) 'Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives'. Journal Of Controlled Release, 296 [DOI] [ULIR Link] [Details]
2019 'Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model'
Sauer A.;Bockmann J.;Steinestel K.;Boeckers T.;Grabrucker A. (2019) 'Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model'. International Journal Of Molecular Sciences, 20 (9) [DOI] [Details]
2019 'Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice'
Sauer A.;Grabrucker A. (2019) 'Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice'. Frontiers In Neuroscience, 13 [DOI] [Details]
2019 'Nanomedicine against Aß aggregation by ß¿sheet breaker peptide delivery: In vitro evidence'
Pederzoli F.;Ruozi B.;Duskey J.;Hagmeyer S.;Sauer A.;Grabrucker S.;Coelho R.;Oddone N.;Ottonelli I.;Daini E.;Zoli M.;Vandelli M.;Tosi G.;Grabrucker A. (2019) 'Nanomedicine against Aß aggregation by ß¿sheet breaker peptide delivery: In vitro evidence'. Pharmaceutics, 11 (11) [DOI] [Details]
2019 'ROS-responsive ¿smart¿ polymeric conjugate: Synthesis, characterization and proof-of-concept study'
Oddone N.;Pederzoli F.;Duskey J.;De Benedictis C.;Grabrucker A.;Forni F.;Angela Vandelli M.;Ruozi B.;Tosi G. (2019) 'ROS-responsive ¿smart¿ polymeric conjugate: Synthesis, characterization and proof-of-concept study'. International journal of pharmaceutics, 570 [DOI] [Details]
2019 'Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI'
Schoen M.;Asoglu H.;Bauer H.;Müller H.;Abaei A.;Sauer A.;Zhang R.;Song T.;Bockmann J.;Kassubek J.;Rasche V.;Grabrucker A.;Boeckers T. (2019) 'Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI'. Frontiers In Neural Circuits, 13 [DOI] [ULIR Link] [Details]
2019 'Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer¿s disease model mice'
Hagmeyer S.;Romão M.;Cristóvão J.;Vilella A.;Zoli M.;Gomes C.;Grabrucker A. (2019) 'Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer¿s disease model mice'. Frontiers In Neuroscience, 13 (JUN) [DOI] [Details]
2018 'Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain'
Belletti, D; Grabrucker, AM; Pederzoli, F; Menrath, I; Vandelli, MA; Tosi, G; Duskey, TJ; Forni, F; Ruozi, B; (2018) 'Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain'. International journal of pharmaceutics, 543 (1-2):300-310 [DOI] [ULIR Link] [Details]
2018 'Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome'
Hagmeyer S;Sauer AK;Grabrucker AM; (2018) 'Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome'. Frontiers In Synaptic Neuroscience, 10 [DOI] [ULIR Link] [Details]
2018 'Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain'
Hagmeyer, S,Cristovao, JS,Mulvihill, JJE,Boeckers, TM,Gomes, CM,Grabrucker, AM (2018) 'Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain'. Frontiers In Molecular Neuroscience, 10 [DOI] [ULIR Link] [Details]
2018 'Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder'
Grabrucker, S,Haderspeck, JC,Sauer, AK,Kittelberger, N,Asoglu, H,Abaei, A,Rasche, V,Schon, M,Boeckers, TM,Grabrucker, AM (2018) 'Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder'. Frontiers In Molecular Neuroscience, 10 [DOI] [Details]
2017 'Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery'
Vilella, A; Belletti, D; Sauer, AK; Hagmeyer, S; Sarowar, T; Masoni, M; Stasiak, N; Mulvihill, JJE; Ruozi, B; Forni, F; Vandelli, MA; Tosi, G; Zoli, M; Grabrucker, AM (2017) 'Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer's disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery'. Journal Of Trace Elements In Experimental Medicine, [DOI] [Details]
2017 'Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC'
Sauer, AK,Pfaender, S,Hagmeyer, S,Tarana, L,Mattes, AK,Briel, F,Kury, S,Boeckers, TM,Grabrucker, AM (2017) 'Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC'. Biometals, 30 :643-661 [DOI] [Details]
2017 'De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability'
Küry, S; van Woerden, GM; Besnard, T; Proietti Onori, M; Latypova, X; Towne, MC; Cho, MT; Prescott, TE; Ploeg, MA; Sanders, S; Stessman, HAF; Pujol, A; Distel, B; Robak, LA; Bernstein, JA; Denommé-Pichon, AS; Lesca, G; Sellars, EA; Berg, J; Carré, W; Busk, ØL; van Bon, BWM; Waugh, JL; Deardorff, M; Hoganson, GE; Bosanko, KB; Johnson, DS; Dabir, T; Holla, ØL; Sarkar, A; Tveten, K; de Bellescize, J; Braathen, GJ; Terhal, PA; Grange, DK; van Haeringen, A; Lam, C; Mirzaa, G; Burton, J; Bhoj, EJ; Douglas, J; Santani, AB; Nesbitt, AI; Helbig, KL; Andrews, MV; Begtrup, A; Tang, S; van Gassen, KLI; Juusola, J; Foss, K; Enns, GM; Moog, U; Hinderhofer, K; Paramasivam, N; Lincoln, S; Kusako, BH; Lindenbaum, P; Charpentier, E; Nowak, CB; Cherot, E; Simonet, T; Ruivenkamp, CAL; Hahn, S; Brownstein, CA; Xia, F; Schmitt, S; Deb, W; Bonneau, D; Nizon, M; Quinquis, D; Chelly, J; Rudolf, G; Sanlaville, D; Parent, P; Gilbert-Dussardier, B; Toutain, A; Sutton, VR; Thies, J; Peart-Vissers, LELM; Boisseau, P; Vincent, M; Grabrucker, AM; Dubourg, C; Tan, WH; Verbeek, NE; Granzow, M; Santen, GWE; Shendure, J; Isidor, B; Pasquier, L; Redon, R; Yang, Y; State, MW; Kleefstra, T; Cogné, B; Petrovski, S; Retterer, K; Eichler, EE; Rosenfeld, JA; Agrawal, PB; Bézieau, S; Odent, S; Elgersma, Y; Mercier, S (2017) 'De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability'. American Journal Of Human Genetics, 101 (5):768-788 [DOI] [Details]
2017 'Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2'
Sarowar, T; Grabrucker, S; Boeckers, TM; Grabrucker, AM (2017) 'Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2'. Frontiers In Neuroscience, 10 (180) [DOI] [ULIR Link] [Details]
2017 'Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates'
Ruozi, B; Belletti, D; Pederzoli, F; Masoni, M; Keller, J; Ballestrazzi, A; Vandelli, MA; Tosi, G; Grabrucker, AM (2017) 'Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates'. International Journal Of Pharmaceutics, [DOI] [ULIR Link] [Details]
2017 'Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3'
Pfaender, S; Sauer, AK; Hagmeyer, S; Mangus, K; Linta, L; Liebau, S; Bockmann, J; Huguet, G; Bourgeron, T; Boeckers, TM; Grabrucker, AM (2017) 'Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3'. Scientific Reports, 7 (45190) [DOI] [ULIR Link] [Details]
2016 'EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION'
Belletti, D; Grabrucker, AM; Pederzoli, F; Menrath, I; Cappello, V; Vandelli, MA; Forni, F; Tosi, G; Ruozi, B (2016) 'EXPLOITING THE VERSATILITY OF CHOLESTEROL IN NANOPARTICLES FORMULATION'. International Journal Of Pharmaceutics, 511 (1):331-340 [DOI] [Details]
2016 'Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies'
Sarowar, T; Grabrucker, AM (2016) 'Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies'. Neural plasticity, 2016: 8051861 [DOI] [ULIR Link] [Details]
2016 'Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency'
Grabrucker, S; Boeckers, TM; Grabrucker, AM (2016) 'Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency'. Frontiers In Behavioral Neuroscience, 10: 37 [DOI] [ULIR Link] [Details]
2016 'Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells'
Pfaender, S; Föhr, K; Lutz, AK; Putz, S; Achberger, K; Linta, L; Liebau, S; Boeckers, TM; Grabrucker, AM (2016) 'Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells'. Neural plasticity, 2016: 3760702 [DOI] [ULIR Link] [Details]
2016 'Activity and circadian rhythm influence synaptic Shank3 protein levels in mice'
Sarowar, T; Chhabra, R; Vilella, A; Boeckers, TM; Zoli, M; Grabrucker, AM (2016) 'Activity and circadian rhythm influence synaptic Shank3 protein levels in mice'. Journal Of Neurochemistry, 138 (6):887-895 [DOI] [Details]
2016 'Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2'
Sarowar, T; Grabrucker, S; Föhr, K; Mangus, K; Eckert, M; Bockmann, J; Boeckers, TM; Grabrucker, AM (2016) 'Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2'. Molecular Brain, 9: 28 [DOI] [ULIR Link] [Details]
2015 'Emerging Use of Nanotechnology in the Treatment of Neurological Disorders'
Chhabra, R; Tosi, G; Grabrucker, AM (2015) 'Emerging Use of Nanotechnology in the Treatment of Neurological Disorders'. Current Pharmaceutical Design, 21 (22):3111-3130 [Details]
2015 'Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo'
Chhabra, R; Ruozi, B; Vilella, A; Belletti, D; Mangus, K; Pfaender, S; Sarowar, T; Boeckers, TM; Zoli, M; Forni, F; Vandelli, MA; Tosi, G; Grabrucker, AM (2015) 'Application of Polymeric Nanoparticles for CNS Targeted Zinc Delivery In Vivo'. Cns & Neurological Disorders-Drug Targets, 14 (8):1041-1053 [Details]
2015 'Zinc in gut-brain interaction in autism and neurological disorders'
Vela, G; Stark, P; Socha, M; Sauer, AK; Hagmeyer, S; Grabrucker, AM (2015) 'Zinc in gut-brain interaction in autism and neurological disorders'. Neural plasticity, 2015: 972791 [DOI] [Details]
2015 'N-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+)'
Heiliger, E; Osmanagic, A; Haase, H; Golenhofen, N; Grabrucker, AM; Weth, A; Baumgartner, W (2015) 'N-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+)'. Metallomics, 7 (2):355-362 [DOI] [Details]
2015 'Effects of trace metal profiles characteristic for autism on synapses in cultured neurons'
Hagmeyer, S; Mangusm K; Boeckers, TM; Grabrucker, AM (2015) 'Effects of trace metal profiles characteristic for autism on synapses in cultured neurons'. Neural plasticity, 2015: 985083 [DOI] [Details]
2014 'Characterization of biometal profiles in neurological disorders'
Pfaender, S; Grabrucker, AM (2014) 'Characterization of biometal profiles in neurological disorders'. Metallomics, 6 (5):960-977 [DOI] [Details]
2014 'Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses'
Baecker, T; Mangus, K; Pfaender, S; Chhabra, R; Boeckers, TM; Grabrucker, AM (2014) 'Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses'. Biometals, 27 (4):715-730 [DOI] [Details]
2014 'Behavioral impairments in animal models for zinc deficiency'
Hagmeyer, S; Haderspeck, JC; Grabrucker, AM (2014) 'Behavioral impairments in animal models for zinc deficiency'. Frontiers In Behavioral Neuroscience, 8: 443 [DOI] [Details]
2014 'Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders'
Grabrucker, S; Jannetti, L; Eckert, M; Gaub, S; Chhabra, R; Pfaender, S; Mangus, K; Reddy, PP; Rankovic, V; Schmeisser, MJ; Kreutz, MR; Ehret, G; Boeckers, TM; Grabrucker, AM (2014) 'Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders'. Brain, 137 (1):137-152 [DOI] [Details]
2014 'The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation'
Grabrucker, S; Proepper, C; Mangus, K; Eckert, M; Chhabra, R; Schmeisser, MJ; Boeckers, TM; Grabrucker, AM. (2014) 'The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation'. Experimental Neurology, 253 :126-137 [DOI] [Details]
2014 'Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release'
Chhabra, R; Grabrucker, AM; Veratti, P; Belletti, D; Boeckers, TM; Vandelli, MA; Forni, F; Tosi, G; Ruozi, B (2014) 'Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release'. International Journal Of Pharmaceutics, 471 (1-2):349-357 [DOI] [Details]
2014 'Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution'
Vilella, A; Tosi, G; Grabrucker, AM; Ruozi, B; Belletti, D; Vandelli, MA; Boeckers, TM; Forni, F; Zoli, M (2014) 'Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution'. Journal Of Controlled Release, 174 :195-201 [DOI] [Details]
2014 'Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport'
Tosi, G; Vilella, A; Chhabra, R; Schmeisser, MJ; Boeckers, TM; Ruozi, B; Vandelli, MA; Forni, F; Zoli, M; Grabrucker, AM (2014) 'Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport'. Journal Of Controlled Release, 177 :90-107 [DOI] [Details]
2013 'The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons'
Schmeisser, MJ; Kühl, SJ; Schoen, M; Beth, NH; Weis, TM; Grabrucker, AM; Kühl, M; Boeckers, TM (2013) 'The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons'. Neural Development, 8: 18 [DOI] [Details]
2012 'Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2'
Schmeisser, MJ; Ey, E; Wegener, S; Bockmann, J; Stempel, AV; Kuebler, A; Janssen, AL; Udvardi, PT; Shiban, E; Spilker, C; Balschun, D; Skryabin, BV; Dieck, St; Smalla, KH; Montag, D; Leblond, CS; Faure, P; Torquet, N; Le Sourd, AM; Toro, R; Grabrucker, AM; Shoichet, SA; Schmitz, D; Kreutz, MR; Bourgeron, T; Gundelfinger, ED; Boeckers, TM (2012) 'Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2'. Nature, 486 (7402):256-260 [DOI] [Details]
2012 'Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling'
Arons, MH; Thynne, CJ; Grabrucker, AM; Li, D; Schoen, M; Cheyne, JE; Boeckers, TM; Montgomery, JM; Garner, CC (2012) 'Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling'. Journal Of Neuroscience, 32 (43):14966-14978 [DOI] [Details]
2012 'Grabrucker AM. Environmental factors in autism'
Grabrucker, AM (2012) 'Grabrucker AM. Environmental factors in autism'. Frontiers in psychiatry, 3: 118 [DOI] [Details]
2011 'Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold'
Grabrucker, AM; Schmeisser, MJ; Udvardi, PT; Arons, M; Schoen, M; Woodling, NS; Andreasson, KI; Hof, PR; Buxbaum, JD; Garner, CC; Boeckers, TM (2011) 'Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold'. Molecular Neurodegeneration, 6: 65 [DOI] [Details]
2011 'Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies'
Grabrucker, AM; Schmeisser, MJ; Schoen, M; Boeckers, TM (2011) 'Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies'. Trends In Cell Biology, 21 (10):594-603 [DOI] [Details]
2011 'Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation'
Grabrucker, AM; Knight, MJ; Proepper, C; Bockmann, J; Joubert, M; Rowan, M; Nienhaus, GU; Garner, CC; Bowie, JU; Kreutz, MR; Gundelfinger, ED; Boeckers, TM (2011) 'Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation'. Embo Journal, 30 (3):569-581 [DOI] [Details]
2011 'Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences'
Grabrucker, AM; Garner, CC; Boeckers, TM; Bondioli, L; Ruozi, B; Forni, F; Vandelli, MA; Tosi, G (2011) 'Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences'. Plos One, 6 (3) [DOI] [Details]
2009 'Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma'
Vellanki, SH; Grabrucker, A; Liebau, S; Proepper, C; Eramo, A; Braun, V; Boeckers, T; Debatin, KM; Fulda, S (2009) 'Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma'. Neoplasia, 11 (8):743-752 [Details]
2009 'Synaptogenesis of hippocampal neurons in primary cell culture'
Grabrucker, A; Vaida, B; Bockmann, J; Boeckers, TM (2009) 'Synaptogenesis of hippocampal neurons in primary cell culture'. Cell And Tissue Research, 338 (3):333-341 [DOI] [Details]
2009 'ynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses'
Schmeisser, MJ; Grabrucker, AM; Bockmann, J; Boeckers, TM (2009) 'ynaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses'. Journal Of Biological Chemistry, 284 (42):29146-29157 [DOI] [Details]
2009 'Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system'
Grabrucker, AM; Vaida, B; Bockmann, J; Boeckers, TM (2009) 'Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system'. Journal Of Neuroscience Methods, 181 (2):227-234 [DOI] [Details]

Editorial

  Year Publication
2017 Molecular and Cellular Mechanisms of Synaptopathies.
Ardiles, AO; Grabrucker, AM; Scholl, FG; Rudenko, G; Borsello, T (2017) Molecular and Cellular Mechanisms of Synaptopathies. Editorial [DOI] [Details]

Professional Associations

  Association Function From / To
International Society for Zinc Biology Member 01-MAR-12 /
Society for Neuroscience Member 03-APR-07 /

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